U.S. Secretary of State Antony Blinken insisted that "the path to diplomacy" is still open in the Middle East despite Israel's latest massive strike targeting Iran-backed Hezbollah's central headquarters in Lebanon, but he insisted Israel and Hezbollah must both "stop firing."
Elsewhere, Iran, Russia, and their allies condemned the strikes on a Beirut suburb -- which Israel TV said was aimed at Hezbollah leader Hassan Nasrallah -- with Tehran calling it a "war crime."
The attacks against Hezbollah came as many world leaders -- including those from the Middle East -- were in New York for the annual UN General Assembly gathering on September 27.
They also came after Israeli Prime Minister Benjamin Netanyahu warned at the UN that his country would continue attacks against Hezbollah in its effort to "degrade" the militant group's capabilities.
The Israeli military acknowledged the attacks but did not directly confirm whether Nasrallah was the target, and his fate remained unknown and subject to widespread speculation in the hours following the action.
SEE ALSO: Israel Targets Hezbollah Leader In Massive Beirut AttackLebanese Prime Minister Najib Mikati urged the global community to "stop" Israel from waging a "genocidal war" against Lebanon.
"This new Israeli aggression proves that the Israeli enemy doesn't care about all the international efforts and calls for a cease-fire," Mikati said.
In a news conference on the sidelines of the General Assembly, Blinken said, "The path to diplomacy may seem difficult to see at this moment, but it is there, and in our judgment, it is necessary. We will continue to work intensely."
"The most important thing to do through diplomacy is to try first to stop firing in both directions and then to use the time that we would have in such a cease-fire to see if we can reach a broader diplomatic agreement."
He added that Israel has a right to defend itself from Hezbollah, which has fired thousands of missiles inside Israeli territory with increased intensity since Israel's war in Gaza began. But he also added that the manner in which it defends itself is also important.
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Leaders from around the world commented on the escalation.
EUROPEAN UNION -- Foreign affairs chief Josep Borrell said, "What we do is to put all diplomatic pressure to a cease-fire, but nobody seems to be able to stop Netanyahu, neither in Gaza nor in the West Bank."
He said the Israeli leader has made it clear his country won't "stop until Hezbollah is destroyed," which will likely mean "a long war."
RUSSIA -- Foreign Minister Sergei Lavrov warned that the Middle East was at the precipice of a "full-blown" war following the strikes in Lebanon.
JORDAN -- Foreign Minister Ayman Safadi told reporters, "It is time to face the truth, and the truth is unless Netanyahu is stopped, unless this government is stopped, war will encompass all of us."
SAUDI ARABIA -- Foreign Minister Prince Faisal bin Farhan Al Saud said Israel's strikes had increased the risk of the situation tumbling out of control.
"We believe very, very, very strongly that a cease-fire is necessary, that the guns are not going to solve anything, that we need to move toward peace in our region, and that peace is firmly rooted in addressing the Palestinian issue," he said.
GERMANY -- Foreign Minister Annalena Baerbock said, "We must avoid Lebanon becoming the next Gaza. This cannot be in Israel's interest either, especially not in terms of security.”
IRAN -- The Iranian Embassy in Lebanon warned of a "dangerous escalation" in the region. "This reprehensible crime...represents a dangerous escalation that changes the rules of the game," it said.
President Masud Pezeshkian also condemned the attacks, calling it a "clear and undeniable war crime."